A deep-sea peptide cluster makes an elastase inhibitor
Myxomiditide A exhibits potent inhibitory activity against elastase while demonstrating moderate inhibition of chymotrypsin.
From a deep-sea genome-mining paper: one product, Myxomiditide A, strongly inhibits elastase and only moderately inhibits chymotrypsin. The biosynthetic gene cluster itself comes from a deep-sea environment. How those enzymes cooperate is the follow-up.
What we can show
Myxomiditide A exhibits potent inhibitory activity against elastase while demonstrating moderate inhibition of chymotrypsin.
Documented1 supporting
The myx BGC is sourced from a deep-sea environment, where gradual environmental shifts may have facilitated the preservation of more ancestral gene sequences.
Documented1 supporting
Sources
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